A National government survey found that 14.5 million people used
marijuana in 2007. By 2013 that had
increased to 19.8 million users. 
That is roughly one million more marijuana users every year. The actual numbers are much more than this
survey indicates, but you get the point.
So, now that we know marijuana use is going up, can I prove that
marijuana really causes PCOS?
Let me remind you that THC (tetrahydrocannabinol) is what causes the
marijuana “high”, and CBD (cannabidiol) doesn’t.
First, we must keep in mind that THC (tetrahydrocannabinol) and CBD (cannabidiol) each react differently within the body’s endocannabinoid system.
Thus, you will have different outcomes when using just one or the
other. Plus, you will have even more
different outcomes when they are used together.
Since experimenting on humans in general, and pregnant women in
particular isn’t ethical, we have to rely on animal tests for our information.
CBD and THC react differently in mice, rats, rabbits, monkeys, and
humans. So, what happens in mice may be
pretty different from what happens in humans.
Giving rats CBD 30 minutes to 24 hours before
giving them THC, increased the effects of the THC.
Whereas, giving monkeys CBD 30 minutes before
giving them THC, reduced the effects of the THC. 
In a human trial, they were given smoke with THC
and CBD at the same time, and the CBD reduced the “high” caused by
the THC. However, when given CBD
smoke 30 minutes before the THC smoke, there was no reduction of the
Also, there is evidence that increasing CBD vs THC
by just 1.8% will increase the effects of THC. Whereas, you may have to increase CBD vs THC
by 800% to decrease the effects of THC. 
That’s right. Less is more, and more is less.
Welcome to the Endocannabinoid System where THC and CBD work their “mysterious magic” on our bodies.
The Endocannabinoid System
The Endocannabinoid System is where marijuana interacts with your body. It does so through receptors that are practically everywhere throughout the body.
There are several types of receptors, but the main THC and CBD receptors are called CB1 and CB2.
There are lots of CB1 receptors in the anterior pituitary, and hypothalamus areas of the brain, where they interact with the central nervous system.
CB1 receptors are also located in the heart, adrenal gland, spleen and
Elsewhere CB1 receptors are also in the human endometrium lining, and the myometrium muscles in the uterus. CB1 receptors are also in the follicles of the ovary. 
CB2 Receptor Locations
receptors interact with the peripheral nervous system, immune system, endometrium,
ovary follicles, and the skin. 
Now we know that the CB1, CB2 receptors of the Endocannabinoid System are
intimately connected to the female reproductive system. So, we still need to know how THC and CBD (?)
in marijuana causes PCOS.
the Menstrual Cycle Starts in the Brain.
The Hypothalamus area of the brain tells the pituitary gland when to make hormones, and also when to stop.
The Pituitary Gland is another area under the brain. It takes the signal
from the Hypothalamus to tell the ovaries to release the estrogen and
progesterone hormones at various times.
Menstrual Cycle and Pregnancy
The hypothalamus tells the pituitary to release the Gonadotrophins
called: Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH).
While the egg moves along the fallopian tube, the progesterone hormone is
released. The progesterone makes the lining
of the uterus to get thicker so that the egg can attach to it, which when
fertilized, results in pregnancy.
The pregnancy somehow creates more estrogen and progesterone to be
released. Which stops any other eggs
At the end of the pregnancy, the high levels of estrogen tell the
pituitary to release oxytocin. 
Oxytocin is what causes the uterine to start contractions. Then the hormone
Relaxin is released by the ovaries, which loosens the pelvic ligaments so
that labor can begin.
What Causes an Ovary Cyst?
cause or causes of PCOS is unknown, but everyone assumes that the menstrual
cycle isn’t working perfectly.  So, I need to show you how marijuana use
could mess things up and cause PCOS.
When you are
born you have an estimated 300,000-400,000 follicles in the ovaries, and you
lose some, every month.  By the time you get to be 40 something years
old, you have practically run out of them.  Averaged out, you are using up about 700 follicles
During the menstrual cycle only one follicle fully matures and produces a sac that contains an egg. If the egg is fertilized, pregnancy begins, if not pregnant, the egg is flushed out during menses.
What Happens to The Follicle After the
Egg is Released?
Normally, after the egg is released from the follicle sac, the sac disappears. However, the sac could close up and contain fluid. That is what is called a luteal cyst. 
If the egg
isn’t released, and the sac fills with fluid, it is called a follicular cyst.
Both the follicular
cyst and the luteal cyst are called Functional
Ovarian Cysts. 
ovarian cysts usually disappear all by themselves. They are not considered to be a problem,
unless they don’t go away on their own.
cyst can grow larger than normal (over 2 inches). That sized cyst is much bigger than the grape
sized ovary, which is why some cysts will twist. A twisted cyst (Torsion cyst) is very
dangerous, because it can cut off the blood supply to the ovary, and needs
immediate medical attention. 
Again, in my
non-medical opinion, before the cyst twists, you are likely to be in so much
pain that you have already seen a doctor.
The Unused Ovary Follicles Cause
The other approximately 700 follicles disappear every month, and I
haven’t seen any info on how that happens.
ovarian cyst requires a follicle to develop within it, and you have 700 of them
available, it’s obvious to me that something happens to them, which results in
As a reminder, PCOS stands for POLY (many) Cysts in the ovaries.
Also, the experts all assume that the cause of PCOS is that something
happens to cause the menstrual system to act abnormally. 
Basically, that means that something upsets the proper quantity of
hormones from being produced and used at the proper times.
That could be lots of things. It
could be the foods you eat, air and water pollution, chemicals added to your
food, and medicines or drugs. Marijuana
Since I have already shown that marijuana use is increasing every year, all I have to do now, is show how marijuana affects the menstrual system.
Upsets the Hormonal System Which Causes PCOS
All of the research that I have found only concerns THC (tetrahydrocannabinol). The research doesn’t mention CBD
(cannabidiol), which is to be expected, since CBD is known to have many
beneficial healing qualities.
In a study using rats, THC reduces the amount of luteinizing hormone that
is released which restrains the process of ovulation.  In other words, a big surge of luteinizing
hormone (called Preovulatory LH Surge) is supposed to be released, but the
“surge” is reduced by the THC.
This means that it could take longer for the egg to develop and be
released.  Which, in my non-doctor opinion, increases the chance of
creating a follicular cyst.
Note: Reducing the “surge” of Luteinizing Hormone
is exactly how Oral Contraceptive Pills work.  That’s also why doctors will
prescribe Contraceptive Pills to prevent you from growing new ovarian cysts.
What is supposed to happen, is that many follicles compete to become the one
to actually produce an egg. However, if
the luteinizing hormone surge is restrained, I am guessing that one of them
doesn’t become dominant,
and doesn’t produce an egg. 
The end result (I’m guessing) is that all of those follicles continue to
develop sacs, with or without eggs.
Again, I’m guessing, that either a dominant follicle never occurs and/or
does not release a healthy egg. Which
would be one cause of infertility.
am saying (in my non-doctor opinion) that THC can cause infertility.
What happens to all those unused, and partially developed follicles? I’m sure (my opinion) that the body will try
to get rid of them.
However, because the menstrual cycle has been interfered with, that could
take some weeks. Which would coincide
with the doctors taking a “wait and see” attitude to see if these “functional
cysts” will disappear on their own.  Normally, that is exactly what
Why Don’t the Ovary Cysts Disappear on Their Own?
Well, if something (diet, pollution, marijuana for instance) has disrupted the menstrual cycle, and that something hasn’t been removed, you should expect to have a continuing problem.
Ways Does THC (Tetrahydrocannabinol) Affect the Menstrual System?
The THC in marijuana attaches to the CB1 and CB2 receptors in the ovary follicles, endometrium lining of the uterus, and the myometrium muscles in the uterus. This could be good or bad, we don’t know yet.
I have already mentioned that THC prevents the release of the necessary amount of luteinizing hormone (LH) for an ovary follicle to develop an egg. It only takes low amounts of THC to interfere with that. Additionally, CBD actually increases the interference that THC produces.  That doesn’t mean that CBD would cause any problem all by itself.
Most street marijuana has high amounts of THC and low amounts of CBD, but any ratio of THC/CBD could cause infertility and PCOS.
That also means that Medical Marijuana, which often times is a 50/50 mix of THC and CBD, will have the same negative results.
THC primarily attaches to the CB1 receptors which are found in the hypothalamus part of the brain and the pituitary gland. Which we have seen are essential to a properly working menstrual cycle, and the prevention of PCOS.
THC interacts with the signaling pathways of the progesterone hormone and dopamine neurotransmitters in the brain, which is probably not a good thing. 
The mitochondria in our body cells produce practically all of the energy used by our body. That includes the energy needed for the brain to function. So, if the hypothalamus and pituitary are starved of energy, chances are pretty good they won’t be signaling the ovaries properly.
One study  showed that THC harms the functioning of the mitochondria in the brain.
You also have mitochondria in the ovaries. So, THC is directly affecting the health of the ovaries by weakening the mitochondria in the ovaries. That includes the follicles in the ovaries, that could develop cysts if not properly nourished by the mitochondria.
on Marijuana and PCOS (Polycystic Ovary Syndrome)
There are probably multiple causes of PCOS, and I have shown that the THC in marijuana is probably one of them.
My non-doctor opinion is based on the fact that THC directly and indirectly
interferes with the menstrual cycle.
There isn’t any direct proof that marijuana causes PCOS, but there is
evidence that it could.
Dare I say, “Where there is Marijuana smoke, there is PCOS.”
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